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Tyramine is a natural substance formed from the breakdown of protein as food ages. It is found in aged, fermented, or spoiled foods. Generally speaking, the longer a high-protein food ages, the greater the tyramine content. Aged cheeses have the highest levels of tyramine. Some foods contain bacterial enzymes that convert tyrosine (an amino acid in foods) to tyramine.
A tyramine-free diet is prescribed for people who are sensitive to tyramine, such as migraine sufferers, or those taking prescription monoamine oxidase inhibitor (MAOI) antidepressants, such as phenelzine (Nardil®). Under normal circumstances, tyramine and dopamine are metabolized to their harmless metabolites by the enzyme monoamine oxidase (MAO). Drugs that inhibit MAO also inhibit the metabolism of tyramine and dopamine, leading to elevated levels of these substances in the bloodstream.
Excessive levels of tyramine can cause headache, palpitations, nausea, vomiting, and hypertensive crisis (dangerously high blood pressure).
To avoid tyramine ask about ingredients at restaurants and others’ homes, and read food labels. The following list is not complete. Consult with a healthcare professional before making any significant changes to your diet. Items listed below that are marked with an asterisk (*) contain high to very high amounts of tyramine.
Dairy products to avoid:
Alcoholic beverages to avoid:
Note: Some experts believe wine and domestic bottled or canned beers are safe when consumed in moderation. Consult your doctor if you are taking MAOI drugs or have migraine headaches and wish to consume wine or domestic beer.
Fruits and vegetables to avoid:
Miscellaneous foods to avoid:
Two cases of a possible interaction between aspartame (NutraSweet®) and phenelzine, an MAOI drug, have been reported.
An analysis of pizzas from large commercial chain outlets found no significant tyramine levels in any of the pizzas tested, including those with double pepperoni and double cheese. The authors of this study concluded that pizzas from large chain commercial outlets are safe for consumption with MAO inhibitors. However, they recommended caution when ordering from smaller outlets or with gourmet pizzas that may use aged cheeses.
The same study found marked variability in the tyramine content of soy products, including significant amounts of tyramine in tofu when stored for a week, and high tyramine content of one of the soy sauces. All soybean products should be avoided.
Herbs Although St. John’s wort contains chemicals that bind MAOI in test tubes, the action of St. John’s wort is not thought to be due to MAOI activity. However, because St. John’s wort may have serotonin reuptake inhibiting action (similar to the action of drugs such as fluoxetine [Prozac®]), it is best to avoid using of St. John’s wort with MAOI drugs. Ephedra (Ephedra sinica), ginseng (species not specified), and Scotch broom (Cytisus scoparius) are also known to interact with phenelzine and should be avoided by anyone taking an MAOI drug.
The following foods are low in tyramine and can be consumed in moderation.
Note: These foods are not tyramine-free. The quantity you eat will affect the amount of tyramine you consume.
Headache and Diet: Tyramine-free Recipes by Seymour Diamond, Diane Francis, Amy Diamond Vye, and others. Madison, CT: International Universities Press, 1990.
The American Pharmaceutical Association
http://www.aphanet.org/
New York Online Access to Health (NOAH)
http://www.noah-health.org/english/illness/mentalhealth/cornell/medications/tyramine.html
Alpers DH, Stenson WF, Bier, DM. Manual of Nutritional Therapeutics. 3rd ed. Boston, MA: Little, Brown and Company; 1995.
Mahan LK, Escott-Stump S. Krause’s Food Nutrition and Diet Therapy. 10th ed. Philadelphia, PA: W.B. Saunders Company; 2000.
Copyright © 2002 Healthnotes, Inc. All rights reserved. www.healthnotes.com
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The information presented in Foodnotes is for informational purposes only and was created by a team of U.S. registered dietitians and food experts. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements, making dietary changes, or before making any changes in prescribed medications. Information expires December 2003.