Adapalene

Also indexed as: Differin®

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Adapalene is a vitamin A–related drug that is applied to the skin to treat acne.

Safetychecker Summary for Adapalene
(for details about the summarized interactions, read the full article)

Depletion or interference

None known

Side effect reduction/prevention

None known

Supportive interaction

None known

Reduced drug absorption/bioavailability

None known

Adverse interaction

None known

An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.

Interaction with Foods and Other Compounds

Topical application of adapalene may cause skin irritation in some individuals. This irritation can be worsened when alcohol, astringents, spices, and lime are also applied to the area.1 Sensitive individuals should use caution when using adapalene and other topical compounds.

References:

1. Sifton DW, ed. Physicians Desk Reference. Montvale. NJ: Medical Economics Company, Inc., 2000, 1104–5.