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Azathioprine is used to prevent organ rejection following kidney transplant and to treat severe cases of rheumatoid arthritis.
Safetychecker Summary
for Azathioprine
(for details about the summarized interactions, read the full article)
 May be Beneficial: Depletion or
interference—The medication may deplete or interfere with the absorption or
function of the nutrient. Taking these nutrients may help replenish them. |
Folic acid |
| Side effect reduction/prevention |
None known |
| Supportive interaction |
None known |
| Reduced drug absorption/bioavailability |
None known |
| Adverse interaction |
None known |
An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.
Interaction with Herbs
Folic acid
People receiving dialysis for kidney failure often have low blood levels of folic acid.
However, folic acid blood levels should return to normal following kidney transplant. A
preliminary study of people taking azathioprine to prevent organ rejection revealed that blood
levels of folic acid remained well below those of individuals not taking the drug. The highest
blood folic acid level was observed in an individual who had not taken azathioprine for two
years.1 Controlled studies are needed to determine whether people taking
azathioprine should supplement with folic acid.
References:
1. Zazgornik J, Druml W, Balcke P, et al. Diminished serum folic acid levels in renal transplant recipients. Clin Nephrol 1982;18:306–10.
Copyright © 2002 Healthnotes, Inc. All rights reserved. www.healthnotes.com
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The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2003.