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Diltiazem is a calcium channel blocker used to treat angina pectoris, heart arrhythmias, and high blood pressure.
Safetychecker Summary
for Diltiazem
(for details about the summarized interactions, read the full article)
 Avoid: Reduced drug absorption/bioavailability—Avoid
these supplements when taking this medication since the supplement may decrease the absorption
and/or activity of the medication in the body. |
DHEA |
| Depletion or interference |
None known |
| Side effect reduction/prevention |
None known |
| Supportive interaction |
None known |
| Adverse interaction |
None known |
An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.
Interactions with Dietary Supplements
Dehydroepiandrosterone
(DHEA)
Diltiazem has been shown to raise blood levels of DHEA and DHEA-sulfate in insulin-resistant,
obese men with high blood pressure.1
Interactions with Herbs
Pleurisy root
As pleurisy root and other plants in the Aesclepius genus contain cardiac glycosides,
it is best to avoid use of pleurisy root with heart medications such as calcium channel
blockers.2
Interactions with Foods and Other Compounds
Food
Diltiazem may be taken with or without food.3 Sustained-release diltiazem products
should be swallowed whole, without opening, crushing, or chewing.4
References:
1. Beer NA, Jakubowicz DJ, Beer RM, Nestler JE. Disparate effects of insulin reduction with diltiazem on serum dehydroepiandrosterone sulfate levels in obese hypertensive men and women. J Clin Endocrinol Metab 1994;79:1077–81.
2. Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-Care Professionals. London: Pharmaceutical Press, 1996, 213–4.
3. Du Souich P, Lery N, Lery L, et al. Influence of food on the bioavailability of diltiazem and two of its metabolites following the administration of conventional tablets and slow-release capsules. Biopharm Drug Dispos 1990;11:137–47.
4. Threlkeld DS, ed. Diuretics and Cardiovasculars, Calcium Channel Blocking Agents. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Mar 1996, 149r–9t.
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The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2003.