Losartan

Losartan is used alone or in combination with hydrochlorothiazide (Hyzaar®) in the treatment of high blood pressure. It is a type of drug called an angiotensin II receptor antagonist.

Safetychecker Summary for Losartan
(for details about the summarized interactions, read the full article)

Check: Other—Before taking any of these supplements or eating any of these foods with your medication, read this article in full for details.	Potassium
Depletion or interference	None known
Side effect reduction/prevention	None known
Supportive interaction	None known
Reduced drug absorption/bioavailability	None known
Adverse interaction	None known

Interactions with Dietary Supplements

Potassium
Losartan has caused significant increases in blood potassium levels.¹ Potassium supplements, potassium-containing salt substitutes (No Salt®, Morton Salt Substitute®, and others), and even high-potassium foods (primarily fruit) should be avoided by those taking losartan, unless directed otherwise by their doctor.

Interactions with Foods and Other Compounds

Food
The intestinal absorption of losartan may be reduced up to 10% if taken with food.² Although this is a minor reduction, losartan should be taken an hour before or two hours after food for maximum effectiveness.

References:

1. Perazella MA. Drug-induced hyperkalemia: Old culprits and new offenders. Am J Med 2000;109:307–14 [review].

2. Sifton DW, ed. Physicians Desk Reference. Montvale, NJ: Medical Economics Company, Inc., 2000, 1769–72.

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The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2003.